Winda Yati
Faculty of Medicine, University of Jember, Jember, Indonesia

Rosita Dewi
Departement of Histology, Faculty of Medicine, University of Jember, Jember, Indonesia

Elly Nurus Sakinah
Departement of Pharmachology, Faculty of Medicine, University of Jember, Jember, Indonesia

Pipiet Wulandari
Department of Cardiology and Vascular Medicine, Dr. Soebandi Regional Hospital, Jember, Indonesia;
Department of Physiology, Faculty of Medicine, University of Jember, Jember, Indonesia

DOI: https://doi.org/10.19184/ams.v11i1.51262

Abstract

Chronic renal failure is a global health problem with the number of sufferers increasing every year. This disease is classified into five stages based on glomerular filtration rate values with or without evidence of kidney damage. In the end stage of chronic renal failure, patients require renal replacement therapy, namely kidney transplantation or hemodialysis. Having hemodialysis therapy is capable cause various complications, one of them is intradialytic hypertension. One of the important things to do to prevent intradialytic hypertension in hemodialysis patent is consuming antihypertensive drugs. The antihypertensive drug is capable of controlling blood pressure, but the usage must be accompanied by patient compliance in consuming the drug to provide long-term treatment effects. If the patient does not obey consuming the drug and their blood pressure cannot be controlled complications will exist, such as organ damage. Therefore, this study aims to determine the relationship between adherence to consuming antihypertensive drugs and intradialytic hypertension in hemodialysis patients. This study used an analytic observational method with a cross-sectional approach. The sample in this study used 88 eligible respondents. The level of drug compliance was measured by using the MMAS-8 (Modified Morisky Adherence Scale) questionnaire, while the blood pressure was measured by using a sphygmomanometer from pre-dialysis to post-dialysis. The data will be processed and analyzed by using the chi-square test. Based on the result of the study obtained a p-value is <0.05 (p-value = <0.001), it can be concluded that there is a relationship between compliance with antihypertensive drug consumption with intradialytic hypertension in hemodialysis patients. These results indicate that medication adherence can reduce the incidence of intradialytic hypertension, thereby improving the quality of life and prognosis of patients undergoing hemodialysis.

Keyword: Intradialytic hypertension, medication adherence, MMAS-8 questionnaire.

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