Afid Brilliana Putra
Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia

Muhammad Imran Khan Ismail
Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia

Awliya
Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia

Gusti Candra Pamungkas
Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia

Nida Ghitha
Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia

Julie Dewi Barliana
Department of Ophthalmology, Faculty of Medicine Universitas Indonesia- Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia

DOI: https://doi.org/10.19184/ams.v10i2.46062

Abstract

The effectiveness of cyclosporine and corticosteroids in treating allergic conjunctivitis in children, including vernal keratoconjunctivitis and atopic keratoconjunctivitis, whether in combination or separately, has been shown to reduce patient symptoms. The aim of this evidence-based case report is to compare the efficacy of corticosteroids and cyclosporine in cases of allergic conjunctivitis. The urgency of this issue lies in the need to identify the most effective and safe treatment for managing severe symptoms in pediatric patients to improve their symptoms. As an illustration, a case of an 8-year-old boy with red, swollen eyes and reduced vision, suspected to be due to allergen exposure. The patient was diagnosed with allergic keratoconjunctivitis and initially treated with Dexamethasone 1 mg eye drops. However, after two weeks of use, only minimal improvement was observed. The eye drops were then replaced with Cyclosporine eye drops to prevent the side effects associated with prolonged use of steroid eye drops. This case report includes a literature analysis comparing the efficacy of topical cyclosporine and corticosteroids in treating severe allergic conjunctivitis. Following a systematic literature review in accordance with PRISMA guidelines, a full-text analysis was conducted on two clinical trials, assessing their validity and applicability based on Oxford CEBM criteria. The literature search results indicate that cyclosporine eye drops administered to patients with severe vernal keratoconjunctivitis can reduce signs and symptoms. When compared with corticosteroids, no significant difference in efficacy was found in cases of allergic conjunctivitis.

Keyword: Cyclosporine; corticosteroid; severe allergic conjunctivitis.

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