Muhammad Andry
Departement of Pharmaceutical Chemistry, Faculty of Pharmacy, Institut Kesehatan Helvetia, Helvetia, Medan, Sumatera Utara, 20124, Indonesia

Muhammad Amin Nasution
Faculty of Pharmacy, Universitas Muslim Nusantara Al Washliyah, Medan, Sumatera Utara, 20147, Indonesia

Firman Rezaldi
4Pharmacy study program at the Mulia High School of Health Sciences, Madiun, East Java, Indonesia

Ade Shindy F Br Sembiring
Faculty of Pharmacy, Institut Kesehatan Helvetia, Helvetia, Medan, Sumatera Utara, 20124, Indonesia

DOI: https://doi.org/10.19184/ams.v9i1.37478

Abstract

Inflammation is a complicated set of tissue alterations resulting from tissue damage caused by microorganisms, trauma, toxins, heat, and pain. The Garcinia xanthochymus is a fruit-bearing tree. Plants of the genus garcinia are abundant in secondary metabolites with potential pharmacological action, including as flavonoids, steroids, and triterpenes. The content of secondary metabolites that are useful as anti-inflammatories are flavonoids. This study aims to investigate the anti-inflammatory efficacy of the stem bark of Garcinia xanthochymus based on the reduction in edema volume. The inquiry was experimental. Through maceration, an ethanol 96% extract of the stem bark was created. The animals were separated into five groups, each with five white male rats. The test given was a suspension of stem bark ethanol extract at 200, 400, and 600 mg/kg BW, a negative control of 1% Na CMC suspension, and a positive control of 2.25 mg/kg sodium diclofenac. Observations were made for 6 hours, and then data were analyzed using a two-way analysis of variance (ANOVA) test. The results showed stem bark ethanol extract was proven to have an anti-inflammatory effect in white male rats induced by carrageenan beginning dosages are 200, 400, and 600 mg/kg, marked by a statistically significant change from the negative control (p<0.05). The 600mg/kg dose group showed no significantly different results from the positive control group (p>.05). These results concluded that the dose group 600mg/kg was the best dose of stem bark ethanol extract had an anti-inflammatory activity based on reducing the volume of leg edema of white male rats.

Keyword: Stem Bark of Garcinia xanthochymus; Anti-Inflammation; Male White Rats.

REFERENCE

1. Alqethami, A., & Aldhebiani, A.Y. (2021). Medicinal plants used in Jeddah, Saudi Arabia: phytochemical screening. Saudi Journal of Biological Sciences, 28(1), 805-812.

2. Amin, M., Silalahi, J., Harahap, U., & Satria, D. (2020). Anti- Inflammation Activity of Virgin Coconut Oil In-Vitro Against Raw Cells 264.7. Asian Journal of Pharmaceutical Research and Development; 8(1), 55-58.

3. Adnyasari, I.A.P.S., Puspawati, N.M., & Sukadana, I.M. (2017). Potensi Antiinflamasi Secara In- Vivo Ekstrak Etanol Batang Antawali (Tinospora sinensis) Pada Tikus Wistar Yang Diinduksi Karagenan. Indones E-Journal Appl Chem, 5(2), 113–119.

4. Andayani, D., Suprihartini, E., & Astuti, M. (2018). Efek Antiinflamasi Ekstrak Etanol Krokot (Portulaca oleracea, L.) pada Udema Tikus yang di Induksi Karagenin. J Pharm Sci Clin Res, 3(1), 43-49.

5. Andry, M., & Faisal, H. (2022). Formulasi dan Uji Aktivitas Antioksidan Sediaan Krim Ekstrak Etanol Daun Asam Jawa (Tamarindus Indica L.) dengan Menggunaan Metode DPPH. Jurnal Dunia Farmasi, 6(2), 96–107.

6. Andry, M., & Winata, H. S. (2022). Uji Aktivitas Antibakteri Streptococcus Mutans serta Formulasi Sediaan Pasta Gigi Ekstrak Etanol Buah Okra Hijau (Abelmoschus esculentus) Dan Tulang Ikan Tuna (Thunnini). Journal of Pharmaceutical and Sciences (JPS), 5(2), 170–173.