Ika Novitasari
Undergraduate Program, Faculty of Medicine, ULM Banjarmasin, South Kalimantan, Indonesia

Hilma Wardatina
Undergraduate Program, Faculty of Medicine, ULM Banjarmasin, South Kalimantan, Indonesia

Lilis Tangkeallo
Undergraduate Program, Faculty of Medicine, ULM Banjarmasin, South Kalimantan, Indonesia

Muhammad Dawud Ashari
Undergraduate Program, Faculty of Medicine, ULM Banjarmasin, South Kalimantan, Indonesia

Isnaini
Department of Pharmacology, Medical Study Program Undergraduate Program, Faculty of Medicine, ULM Banjarmasin, South Kalimantan Indonesia

DOI: https://doi.org/10.19184/ams.v8i1.27451

Abstract

Wound is an incontinence condition of skin or mucosal epithelial tissue due to physical or thermal damage. One of the wound therapies can use plants or compounds that are antiseptic or anti-bacterial, in addition to being anti-inflammatory and re-epithelializing. The plant that has the potential as a wound healing is galam (Melaleuca cajuputi subsp. Cumingiana (Turcz.) Barlow). Galam flower methanol extract has antibacterial activity with a minimum inhibitory level of 1.7 mg/mL. This research analyze the wound healing activity of galam flower extract in Wistar strain rats that were initiated by the wound seen from the histology of the rat skin. This research uses posttest only method with control group design. Thirty wistar rats were divided into five groups consisting of a positive control group, a negative control group, 1% galam flower extract gel, 2% galam flower extract gel, and 4% galam flower extract gel. Based on histological data, the positive control treatment group and 4% gel treatment group gave the same results. Both indicate that the skin tissue has begun to connect. The conclusions the three galam flower methanol extract gel formulas showed wound healing activity and the 4% galam flower methanol extract gel gave the greatest wound healing activity.

Keyword: Melaleuca cajuputi subsp. Cumingiana (Turcz.) Barlow, antibacterial activity, wound initiated healing.

REFERENCE

1. Al-Abd NM, et al. 2015. Antioxidant, antibacterial activity, and phytochemical characterization of Melaleuca cajuputi extract. BMC Complementary and Alternative Medicine 15(1): 1–13.

2. Anderson K, Hamm RL. 2012. Factors that impair wound healing. Journal of the American College of Clinical Wound Specialists 4(4): 84–91.

3. Commander SJ, et al. 2016. Update on postsurgical scar management. Seminars in plastic surgery. Thieme Medical Publishers: 122–128.

4. Guo S, DiPietro LA. 2010. Factors affecting wound healing. Journal of Dental Research 89(3): 219–229.

5. Han X, Tory PL. 2017. Melaleuca (Melaleuca alternifolia) essential oil demonstrates tissue-remodeling and metabolism-modulating activities in human skin cells. Cogent Biology 3(1): 1–7.

6. Hess CT. 2011. Checklist for factors affecting wound healing. Advances in Skin & Wound Care 24(4): 192.

7. Isnaini, et al. 2021. Aktivitas antibakteri dan antijamur ekstrak galam (Melaleuca cajuputi subsp. Cumingiana (Turcz) terhadap bakteri E.coli dan jamur C.albicans. Journal of Agromedicine and Medical Sciences 7(2): 79–83.