Akhmad Makhmudi
Faculty of Medicine Gadjah Mada University, Yogyakarta, Indonesia

Azka Darajat
PANAH Research Center, Faculty of Medicine Universitas Jember, Jember, East Java, Indonesia

Elly Nurus Sakinah
PANAH Research Center, Faculty of Medicine Universitas Jember, Jember, East Java, Indonesia

Muhammad Yuda Nugraha
PANAH Research Center, Faculty of Medicine Universitas Jember, Jember, East Java, Indonesia

Achmad Ilham Tohari
PANAH Research Center, Faculty of Medicine Universitas Jember, Jember, East Java, Indonesia

Tegar Syaiful Qodar
PANAH Research Center, Faculty of Medicine Universitas Jember, Jember, East Java, Indonesia

Bagus Wahyu Mulyono
PANAH Research Center, Faculty of Medicine Universitas Jember, Jember, East Java, Indonesia

DOI: https://doi.org/10.19184/ams.v8i1.25715

Abstract

Early diagnosis of pediatric appendicitis is still difficult to make and 30-40% of cases do not show typical classic symptoms. The negative appendectomy rate and the risk of perforation reach 20% so that new, easy, inexpensive and accurate additional examination is needed. This study aimed to compare platelet distribution width (PDW) and mean platelet volume (MPV) values of appendicitis and control patients. This study is retrospective case control study. Differences in MPV and PDW levels in patients with appendicitis and controls were analyzed with a t-test and determination of sensitivity, specificity and accuracy of the two markers in appendicitis diagnosis were performed by ROC analysis The mean MPV appendicitis was significantly lower (p <0.05) compared to controls (8.3 ± 1.9; 9.2 ± 1.5) while PDW of appendicitis patients did not differ significantly from controls (10.4 ± 1, 4, 10.7 ± 2.4; p> 0.05). AUC MPV as a diagnostic tool for appendicitis 0.619 with a normal limit of 6.6 fl has a sensitivity of 90% and specificity of 30%. MPV can be used for the diagnosis of appendicitis with a normal limit of 6.6 fl having a sensitivity of 90% and specificity of 30%. There was no significant difference between PDW of appendicitis patients with controls. There was no significant difference between MPV levels of patients with simple appendicitis and complications.

Keyword: Appendicitis, MPV, PDW, Platelet.

REFERENCE

1. Al-gaithy, Z. K. (2012). Clinical value of total white blood cells and neutrophil counts in patients with suspected appendicitis: retrospective study. World Journal of Emergency Surgery, 7(1), 1–7. https://doi.org/10.1186/1749-7922-7-32

2. Albayrak, Y., Albayrak, A., Albayrak, F., Yildirim, R., Aylu, B., Uyanik, A., ... Güzel, I. C. (2011). Mean platelet volume: A new predictor in confirming acute appendicitis diagnosis. Clinical and Applied Thrombosis/Hemostasis, 17(4), 362–366. https://doi.org/10.1177/1076029610364520

3. Aydogan, A., Akkucuk, S., Arica, S., Motor, S., Karakus, A., Ozkan, O. V., ... Temiz, M. (2015). The Analysis of Mean Platelet Volume and Platelet Distribution Width Levels in Appendicitis. Indian Journal of Surgery, 77(December), 495–500. https://doi.org/10.1007/s12262-013-0891-7

4. Bergeron, E. (2006). Clinical judgment remains of great value in the diagnosis of acute appendicitis. Canadian Journal of Surgery, 49(2), 96–100.

5. Bilici, S., Sekmenli, T., Göksu, M., Melek, M., & Avci, V. (2011). Mean platelet volume in diagnosis of acute appendicitis in children. African Health Sciences, 11(3), 427–432.

6. Bozkurt, S., Köse, A., Erdogan, S., Bozali, G. I., Ayrik, C., Arpaci, R. B., ... Türkmenoglu, Ö. (2015). MPV and other inflammatory markers in diagnosing acute appendicitis. Journal of the Pakistan Medical Association, 65(6), 637–641.