Tsabita Nafisa
Faculty of Medicine, University of Jember, Jember, Indonesia

Muhammad Syifaul Afnan
Faculty of Medicine, University of Jember, Jember, Indonesia

Made Prasanti Andriani
Faculty of Medicine, University of Jember, Jember, Indonesia

Cika Abadi Laily Widanto
Faculty of Medicine, University of Jember, Jember, Indonesia

Desie Dwi Wisudanti
Department of Pharmacology, Faculty of Medicine, University of Jember, Jember, Indonesia

DOI: https://doi.org/10.19184/ams.v11i2.24051

Abstract

Tuberculosis (TB) is a global disease that poses a significant public health threat, capable of causing death and affecting individuals of all ages. By the year 2020, Indonesia is the top three countries number of tuberculosis (TB) cases identified, including among both adult and child populations. Jember district has the second-highest number of TB cases in East Java, after Surabaya City, with a total of 5,244 cases in adults and 478 cases in children. The identification of pediatric TB cases is imperative for the management of the disease, as children under the age of 14 represent 12% of the population. However, the implementation of Tuberculosis Preventive Therapy (TPT), a government program aimed at strengthening the management of Infectious Latent Tuberculosis (ILTB), remains inadequate. Infants who have close contact with drug-sensitive TB (SO TB) patients are at elevated risk of infection and, as a result, require TPT. The objective of this study was to analyze the factors of drivers, enablers, reinforcers, and the role of Drug Swallowing Supervisors (PMOs) on adherence to medication in the TPT program for TB close contact toddlers in Jember District. The present study employed an explanatory method to test hypotheses and to ascertain relationships between variables. The findings indicated that predisposing factors (p-value 0.000), enabling factors (p-value 0.013), reinforcing factors (p-value 0.049), and the role of PMO had a significant effect on medication adherence. The success of the TPT program is primarily attributable to two factors: family support and the role of PMO.

Keyword: CYP51, Dandruff, Leucaena leucocephala, Malassezia furfur, Natural antifungal.

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